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UCHL5

Ubiquitin carboxyl-terminal hydrolase isozyme L5;Isoform 2 of Ubiquitin carboxyl-terminal hydrolase isozyme L5; Isoform 4 of Ubiquitin carboxyl-terminal hydrolase isozyme L5; Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5

Protease that specifically cleaves ‘Lys-48’-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • UCHL5

UniProt ID

  • Q9Y5K5
  • Q9Y5K5-2
  • Q9Y5K5-4
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