Discovery proteomics services

Our high-specificity discovery proteomics method is built to align with your coverage and throughput needs.

Deep coverage of the blood and tissue proteome at the speed and scale your study demands.

Like metabolites and lipids, proteins are dynamic indicators of health, disease, and drug response. Explore more of the proteome with our nontargeted proteomics approaches.

Leveraging our high throughput mass spectrometry platform, Sapient’s method achieves high analytical specificity while optimizing for protein coverage and throughput to best suit your bioanalytical needs.

Sapient
/HT/ Discovery

Optimized for throughput and robustness across large, population-scale studies.

Sapient
/Core/ Discovery

Assays >4,000 proteins and PTMs to reveal new biological insights from the proteome.

Sapient
/Deep/ Discovery

Ideal for cell- and tissue-based studies when the deepest proteome coverage is required.

High throughput mass spectrometry to directly measure more proteins and proteoforms.

discovery proteomics services

Sapient can capture biologically significant signals in the low abundance proteome using nanoparticle capture to simultaneously deplete high abundant proteins and enrich low abundant proteins.

Sapient’s discovery proteomics method uses nanoLC coupled to trapped ion mobility mass spectrometry and nanoparticle enrichment to:

  • Measure thousands of PTMs and protein variants, capturing biologically important structural changes for more in-depth analysis of protein function and regulation
  • Achieve high confidence protein identification via direct peptide sequencing
  • Enable analysis in multiple liquid and tissue biomatrices, including from preclinical and clinical systems
  • Provide experimental flexibility for custom protein panels, including for difficult-to-measure proteins
discovery proteomics services mass spectrometry

Multi-omics data integration to make protein biomarkers actionable.

Our data science team can provide integrative analysis of proteomics data with the metabolomics data we generate as well as with genomics, phenotype information, and clinical inputs to elucidate protein biomarkers and their involvement in the dynamic processes underlying disease and drug response.

For example, we can perform pathway and tissue enrichment analysis across 9 key biological processes, 40+ tissue signaling pathways, and 28 tissues of origin in plasma.

What are you looking to identify?

The right patient.

  • Responders / non-responders
  • Patient stratification
  • Safety profiling
  • Companion diagnostics
  • Clinical trial enrichment

The right disease.

  • Target ID and validation
  • Disease mechanisms
  • Early disease detection
  • Disease progression

The right therapy.

  • Dosing strategies
  • Timing of treatments
  • Target engagement
  • Toxicology
discovery proteomics services partner

What makes our discovery proteomics services revolutionary in the market?​

high throughput proteomics

PharmaShots: “Shedding Light on Sapient’s Recently Launched Discovery Proteomics Services”

proteomics for protacs and molecular glues

Deep Discovery Proteomics for PROTACs and Molecular Glues

cell surface proteomics for adc development

Deep Discovery Proteomics in ADC Development: Profiling Cell Surface TAAs

mass spectrometry proteomics

Advancing Clinical Biomarkers through Mass Spectrometry-based Discovery Proteomics

mass spec proteomics

Sapient Discovery Proteomics Differentiators

multi-omics biomarker discovery services

Sapient Multi-Omics Biomarker Discovery Services

Ready to discover more?

Use the form to request proteomics services. If you have questions, we encourage you to meet with our team.

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