Discovery proteomics services

Our high-specificity discovery proteomics methods are built to align with your coverage and throughput needs, and optimized for your sample type.

High throughput proteomics to measure thousands of proteins at a time in diverse sample matrices.

Leveraging state-of-the-art mass spectrometry, our discovery proteomics methods deliver high-confidence annotations of proteins and their isoforms while optimizing for coverage and throughput to best suit your study requirements at each phase.

These methods are optimized to interrogate thousands of proteins per sample and include:

Plasma Proteomics

Measure of 5,400+ protein groups with exceptional reproducibility (~5% CV).

CSF
Proteomics

Profiling of 3,600+ protein groups including known targets of CNS disease.

Saliva
Proteomics

Measure of 6,000+ protein groups to non-invasively probe systemic health.

Tumor
Proteomics

Measure of 12,000+ protein groups including tumor antigens and intracellular proteins.

Urine
Proteomics

Profiling of 4,000+ proteins groups including >500 known & emerging drug targets.

High throughput mass spectrometry to directly measure more proteins and proteoforms.

discovery proteomics services

Sapient can capture biologically significant signals in the low abundance proteome using nanoparticle enrichment to simultaneously deplete high abundant proteins and enrich low abundant proteins.

Sapient’s label-free, DIA discovery proteomics methods use nanoflow separation coupled to trapped ion mobility mass spectrometry and nanoparticle enrichment to enable:
  • Measure thousands of PTMs and protein variants, capturing biologically important structural changes for more in-depth analysis of protein function and regulation
  • Capture of exosomal and membrane-bound proteins
  • High confidence protein identification via direct peptide sequencing
  • Scalable depth of protein coverage in biofluids using specialized ‘capture-and-hold’ nanoparticle chemistry for high quantitative accuracy
  • Applicability across species including preclinical and clinical models
discovery proteomics services mass spectrometry

Multi-omics data integration to make protein biomarkers actionable.

Our data science team can provide integrative analysis of proteomics data with the metabolomics data we generate as well as with genomics, phenotype information, and clinical inputs to elucidate protein biomarkers and their involvement in the dynamic processes underlying disease and drug response.

We do this by leveraging our DynamiQ™ Insights Engine to perform at-scale analyses that elucidate:

The right patient.

  • Responders / non-responders
  • Patient stratification
  • Safety profiling
  • Companion diagnostics
  • Clinical trial enrichment

The right disease.

  • Target ID and validation
  • Disease mechanisms
  • Early disease detection
  • Disease progression

The right therapy.

  • Dosing strategies
  • Timing of treatments
  • Target engagement
  • Toxicology
discovery proteomics services partner

What makes our discovery proteomics services revolutionary in the market?​

dark proteome services

Illuminating the Dark Proteome

plasma proteomics

Plasma Proteomics 2025: Potential Realized and the Insights Drug Developers Can Expect

saliva protein assays

Sapient Saliva Protein Assays

csf proteomics services

Sapient CSF Proteomics

plasma proteomics services

Sapient Plasma Proteomics

companion diagnostic development proteins

The Next Frontier in CDx: Protein-Based Companion Diagnostics

Ready to discover more?

Use the form to request proteomics services. If you have questions, we encourage you to meet with our team.

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