Our Technology

Driven by technology, supported by data, focused on insight.

Our discovery pipeline combines next-generation mass spectrometry technology, computational analysis, and large-scale human biology data.

Advancing precision medicine demands greater discovery of biomarkers that improve our understanding of complex diseases and identify patients most likely to benefit from specific treatments. Sapient’s platform, built on proprietary next-gen mass spec systems and an expansive Human Biology Database, multiples the rate of small molecule biomarker discovery to help biopharma sponsors maximize drug development success.

Find biomarkers that matter most, at unmatched speed

Sapient can rapidly assay thousands of small molecule biomarkers, including uncharacterized compounds, in your biological samples.

Accelerate development with deeper insight

Leverage our Human Biology Database to evaluate identified biomarkers in independent biosamples or to mine for new discoveries.

Engage Us Today

Sapient’s Core Technology

Take a closer look at our platform.

Leverage Sapient’s method for untargeted biomarker profiling to significantly amplify your discovery potential. Then use our expert data science team and vast human chemical databases to interpret, validate, and translate those discoveries for clinical impact.

mass spec system for biomarker discovery
Analytical Technologies

Sapient’s next-generation rapid liquid chromatography-mass spectrometry (rLC-MS) infrastructure and automated workflows scale the speed and capacity of current analytical technologies, assaying >11,000 small molecule biomarkers per biosample in less than 1 minute per sample. Using untargeted molecular profiling, these systems enable discovery of uncharacterized compounds.

next-gen mass spec system
next-generation mass spectrometry system
analyzing mass spec data
Computational Analysis

Applying statistical and machine learning tools to the generated data, Sapient’s expert data science team enables identification of key molecules that provide actionable insights for your drug development program, such as biomarkers of target engagement, biological processes, disease progression, or adverse events.

mass spec data analysis
spectral data analysis
database of small molecule measures
Human Biology Database

Sapient’s expansive repository is comprised of data from hundreds of thousands of human biosamples, including >10-30 years of follow-up information across patients. We use this data to amplify discovery potential, to confirm biomarker findings in independent samples and to validate preclinical and clinical discoveries.

database of spectral data
spectral data database

Collectively, these technologies enable Sapient to:

  • Identify key biological mechanisms of disease

  • Confirm pharmacological engagement of key targets

  • Provide early insight into potential drug safety risks

  • Uncover dosing and timing of drug targets

  • Align patients, disease biology, and specific therapies

A Culture of Quality

Consistency, collaboration, and radical transparency.

We pride ourselves on upholding rigorous quality standards and adhere to stringent regulatory standards in practice. After we identify biomarkers of interest through initial rLC-MS discovery screening, we can use more traditional targeted methods to confirm key signals and translate specific metabolites into clinical assays for use in GLP or CLIA settings.