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Discover dynamic biomarkers beyond the genome.

Our large-scale multi-omics analyses give you an unprecedented view into the factors that modulate health, disease, and drug response across individuals and over time.

EXPLORE SERVICES

One sample, multiple measures, greatly expanded phenotypic insights.

Sapient is a purpose-built biomarker discovery organization providing bespoke multi-omics services for metabolomics, lipidomics, and proteomics data generation and analysis.

Discovery metabolomics and lipidomics at unmatched speed and scale.

Sapient’s next-generation, high throughput mass spectrometry systems capture diverse metabolite and lipid chemistries in a single run.

  • >15K small molecule biomarkers measured per biosample
  • High throughput capacity to handle 5K+ samples per day
  • In-house library of >10,000 reference standards for robust metabolite identification
  • Mapping of biologically relevant unknown molecules for novel discovery
EXPLORE METHOD

Focused small molecule biomarker discovery analyses with rapid time-to-insight.

Sapient’s suite of panels enable targeted exploration of small molecules in specific chemical classes and commonly associated with health and disease.
  • Ready-to-order panels with customization available
  • High-sensitivity measures to detect subtle changes in biomarker levels for known metabolites and/or lipids of interest
  • Analyzed using high throughput mass spectrometry for rapid turnaround of insights
EXPLORE PANELS

High throughput, nontargeted proteomics to meet your study needs for coverage and throughput.

Sapient’s mass spectrometry-based discovery proteomics method extends multi-omics insights with deep coverage of the blood and tissue proteome.

  • Analytical specificity for high-confidence protein and post-translational modification (PTM) annotation via direct peptide sequencing
  • Depth and breadth to measure thousands of proteins and PTMs across diverse biological pathways – 6K+ in plasma and 12K+ in cells and tissue
  • High throughput approach with scalability to process thousands of samples
SEE APPROACHES

High-accuracy measures for specific protein biomarkers and targets of interest.

Sapient leverages its mass spectrometry systems for the quantitative measure of key proteins and PTMs in plasma, cells, and tissue.

  • Expansive menu of >12,000 ‘off-the-shelf’ targeted protein assays which can be rapidly optimized to your study requirements
  • Custom assay development for difficult-to-measure proteins and proteoforms
  • Scalable multiplexing while maintaining high specificity and reproducibility
VIEW ASSAYS
multi-omics analyses

Through our integrated multi-omics services, we generate greater biological insight from every sample to help you better understand disease and accelerate drug development.

Amplify actionable insight with our integrative multi-omics data analysis.

We offer expert data analysis services to help you map the genetic and phenotypic associations of your identified biomarkers.

BIOCOMPUTATIONAL SERVICES

Gain a comprehensive view of underlying disease biology and drug effects.

Our team uses advanced statistical and ML tools to amalgamate multi-omics, preclinical, and clinical data with human health metadata.

SEE APPROACH
BIOMARKER CROSS-VALIDATION

Understand how your biomarker behaves across large, diverse populations.

Using Sapient’s proprietary Human Biology Database, comprised of data from 100K+ biosamples with paired genetic, phenotypic, and clinical information.

EXPLORE THE DATA
multi-omics data analysis

Your multi-omics services partner.

Sapient was founded on a core set of discovery values that we bring to every client collaboration, and that we believe are critical to accelerate drug development success.

Rapid time-to-insight.

We know our data drives your
decision-making and have capacity to ensure fast turnaround of results.

Transparent science.

We believe it essential that you have full access to and ownership of your data and findings.

Innovative methods.

We utilize novel technologies and deep expertise to assay thousands of dynamic, non-genetic biomarkers.

Efficient translation.

Our pipeline spans biomarker discovery, validation, and translation, including a CLIA-certified, CAP-accredited lab.
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analysis of multi-omics data
multi-omics CRO

Explore the science.

  • White Paper
clinical protein assays elisa mass spectrometry

Rethinking Clinical Protein Assays: ELISA vs. Mass Spectrometry
  • Media
diagnostic biomarker development persistent lyme disease

Sapient and Bay Area Lyme Foundation Advance Multi-Biomarker Diagnostic Test for Persistent Lyme Disease
  • Video
multi-omic data integration interpretation

Panel Discussion: Overcoming Challenges of Integrating Multi-Omic Data
  • Article
metabolite profiling for identification

Improving metabolite identification in nontargeted metabolomic and lipidomic studies
  • Media
radioligand development

Aventine Feature: 5 Ways to Think About Radioligands
  • Webinar
target discovery

Differential, Disease Modifying, Tractable: Identifying Optimal Drug Targets with Discovery Proteomics and AI

Ready to discover more?

Connect with our scientists to discuss your project or the biological questions you want to answer. We’re here to help you apply our unique multi-omics services at any phase of development.

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10421 Wateridge Circle, Suite 100
San Diego, CA 92121

discover@sapient.bio
858.290.7010

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