Isoform 4 of Serine/threonine-protein kinase SIK3;Serine/threonine-protein kinase SIK3; Isoform 2 of Serine/threonine-protein kinase SIK3

Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • SIK3

UniProt ID

  • Q9Y2K2
  • Q9Y2K2-8

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