SERPINE1 mRNA-binding protein 1;Isoform 3 of SERPINE1 mRNA-binding protein 1

Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3′-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • SERBP1

UniProt ID

  • Q8NC51
  • Q8NC51-3

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