RGS6;RGS7

Isoform 3 of Regulator of G-protein signaling 7; Isoform 12 of Regulator of G-protein signaling 6; Isoform 2 of Regulator of G-protein signaling 6; Isoform 2 of Regulator of G-protein signaling 7; Isoform 3 of Regulator of G-protein signaling 6; Isoform 15 of Regulator of G-protein signaling 6; Isoform 8 of Regulator of G-protein signaling 6; Isoform 10 of Regulator of G-protein signaling 6; Isoform 16 of Regulator of G-protein signaling 6; Isoform 7 of Regulator of G-protein signaling 6; Isoform 13 of Regulator of G-protein signaling 6;Regulator of G-protein signaling 6; Isoform 11 of Regulator of G-protein signaling 6; Isoform 14 of Regulator of G-protein signaling 6; Isoform 4 of Regulator of G-protein signaling 7; Isoform 5 of Regulator of G-protein signaling 6; Isoform 5 of Regulator of G-protein signaling 7; Isoform 6 of Regulator of G-protein signaling 6; Isoform 9 of Regulator of G-protein signaling 6; Regulator of G-protein signaling 7

GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:10521509, PubMed:10862767, PubMed:31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed:12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • RGS7

UniProt ID

  • P49758
  • P49758-11
  • P49758-12
  • P49758-13
  • P49758-14
  • P49758-15
  • P49758-16
  • P49758-2
  • P49758-3
  • P49758-5
  • P49758-6
  • P49758-7
  • P49758-8
  • P49758-9
  • P49802
  • P49802-2
  • P49802-3
  • P49802-4
  • P49802-5P49802-5
Off-the-shelf

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