RBG1L

Isoform 7 of Rab GTPase-activating protein 1-like; Isoform 6 of Rab GTPase-activating protein 1-like; Isoform 8 of Rab GTPase-activating protein 1-like;Isoform 5 of Rab GTPase-activating protein 1-like; Isoform 3 of Rab GTPase-activating protein 1-like; Isoform 4 of Rab GTPase-activating protein 1-like; Isoform 2 of Rab GTPase-activating protein 1-like;Rab GTPase-activating protein 1-like

GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • RABGAP1L

UniProt ID

  • Q5R372
  • Q5R372-3
  • Q5R372-4
  • Q5R372-5
  • Q5R372-7
  • Q5R372-8
Off-the-shelf

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