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PKHG5

Pleckstrin homology domain-containing family G member 5; Isoform 4 of Pleckstrin homology domain-containing family G member 5; Isoform 3 of Pleckstrin homology domain-containing family G member 5; Isoform 2 of Pleckstrin homology domain-containing family G member 5

Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • PLEKHG5

UniProt ID

  • O94827
  • O94827-4
  • O94827-7
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