APC15

Isoform 2 of Anaphase-promoting complex subunit 15;Anaphase-promoting complex subunit 15

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • ANAPC15

    UniProt ID

    • P60006

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