Resource Library

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Hypoxanthine—early biomarker of outcomes in an ovine model of neonatal hypoxic ischemic encephalopathy

This paper details the use of Sapient's discovery metabolomics method to uncover an early biomarker of HIE.

Protocol: the International Milk Composition (IMiC) Consortium – a harmonized secondary analysis of human milk from four studies

Describing an untargeted metabolomics analysis protocol to explore metabolites that may contribute to infant growth.

Sapient publishes breakthrough rLC-MS metabolomics study in over 26,000 samples, revealing metabolic aging clock and disease insights

Detailing the rLC-MS method & its use to predict clinically relevant physiological states at scale in human populations.

Rapid Liquid Chromatography-Mass Spectrometry (rLC-MS) for Deep Metabolomics Analysis of Population Scale Studies

This breakthrough mass spectrometry metabolomics study in >26,000 samples led to development of a metabolic aging clock.

Isotope tracing-based metabolite identification for mass spectrometry metabolomics

This paper describes a new approach to metabolite ID & how it was used to discover a novel metabolite biomarker.

Plasma Lipid Metabolites, Clinical Glycemic Predictors, and Incident Type 2 Diabetes

This paper, published in Diabetes Care, identifies key metabolites associated with incident type 2 diabetes (T2D).

Sapient Contributes to Landmark Study Published in Science Linking Lysosomal Biology and Oxysterol Metabolism to Pulmonary Arterial Hypertension (PAH)

This multi-omics study, led by UPitt researchers, establishes causative linkages between key metabolites & PAH.

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

This paper, published in Science, establishes a genetic & metabolic paradigm linking key metabolites to PAH.

Sapient Contributes to Groundbreaking Study on Human Liver Metabolism Published in <em>Nature Metabolism</em>

The paper details an innovative approach for assaying metabolic activities in intact human liver tissue.

Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo

This paper, published in Nature Metabolism, details a study making significant strides in the understanding human liver metabolism.

Reconstructing the landscape of gut microbial species across 29,000 diverse individuals

There is increasing evidence of the human gut microbiome’s link to health and disease. Exploring the composition and function of…

University of Oxford Publishes Findings from Its INTERBIO-21st Study Supported by Sapient’s Discovery Metabolomics

September 1, 2022—San Diego, CA—A study led by researchers at the University of Oxford, UK has been published in Lancet Diabetes…