Isoform 2 of Src kinase-associated phosphoprotein 1;Src kinase-associated phosphoprotein 1

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • SKAP1

UniProt ID

  • Q86WV1

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