S35A3

Isoform 2 of UDP-N-acetylglucosamine transporter;UDP-N-acetylglucosamine transporter; Isoform 3 of UDP-N-acetylglucosamine transporter

Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:10393322). May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (PubMed:23766508, PubMed:34981577). However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (PubMed:32938718). {ECO:0000269|PubMed:10393322, ECO:0000269|PubMed:23766508, ECO:0000269|PubMed:32938718, ECO:0000269|PubMed:34981577}.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • SLC35A3

UniProt ID

  • Q9Y2D2
  • Q9Y2D2-3
Off-the-shelf

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