RFC1

Replication factor C subunit 1; Isoform 2 of Replication factor C subunit 1

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. ; Interacts with C-terminus of PCNA. 5′ phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • RFC1

UniProt ID

  • P35251
Off-the-shelf

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