Isoform 3 of Sphingomyelin phosphodiesterase 4; Isoform 2 of Sphingomyelin phosphodiesterase 4;Sphingomyelin phosphodiesterase 4; Isoform 4 of Sphingomyelin phosphodiesterase 4

Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity). {ECO:0000250|UniProtKB:Q6ZPR5, ECO:0000269|PubMed:16517606, ECO:0000269|PubMed:18505924, ECO:0000269|PubMed:25180167, ECO:0000269|PubMed:31495489}.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • SMPD4

UniProt ID

  • Q9NXE4
  • Q9NXE4-3
  • Q9NXE4-4

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