NRAM2

Natural resistance-associated macrophage protein 2; Isoform 5 of Natural resistance-associated macrophage protein 2; Isoform 4 of Natural resistance-associated macrophage protein 2; Isoform 3 of Natural resistance-associated macrophage protein 2; Isoform 1 of Natural resistance-associated macrophage protein 2; Isoform 4 of Natural resistance-associated macrophage protein 2;Isoform 3 of Natural resistance-associated macrophage protein 2

Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity) (PubMed:24448823). Can mediate uncoupled fluxes of either protons or metal ions. {ECO:0000250|UniProtKB:O54902, ECO:0000250|UniProtKB:P49282, ECO:0000269|PubMed:17109629, ECO:0000269|PubMed:17293870, ECO:0000269|PubMed:22736759, ECO:0000269|PubMed:24448823, ECO:0000269|PubMed:25326704, ECO:0000269|PubMed:25491917}.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • SLC11A2

UniProt ID

  • P49281
  • P49281-3
  • P49281-4
  • P49281-5
Off-the-shelf

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