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FBX22

F-box only protein 22

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • FBXO22

    UniProt ID

    • Q8NEZ5
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