EDEM3

Isoform 2 of ER degradation-enhancing alpha-mannosidase-like protein 3;ER degradation-enhancing alpha-mannosidase-like protein 3

Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans (PubMed:25092655). May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • EDEM3

    UniProt ID

    • Q9BZQ6

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