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TOPK

Lymphokine-activated killer T-cell-originated protein kinase

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • PBK

UniProt ID

  • Q96KB5
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