EIF3B

Eukaryotic translation initiation factor 3 subunit B; Isoform 2 of Eukaryotic translation initiation factor 3 subunit B;Eukaryotic translation initiation factor 3 subunit B

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). ; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • EIF3B

UniProt ID

  • P55884

Request the EIF3B Assay

Tell us a little more about your study so we can optimize the assay for your specific needs.

"*" indicates required fields

This field is for validation purposes and should be left unchanged.