EI2BD

Translation initiation factor eIF2B subunit delta;Isoform 2 of Translation initiation factor eIF2B subunit delta; Isoform 3 of Translation initiation factor eIF2B subunit delta

Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • EIF2B4

UniProt ID

  • Q9UI10
  • Q9UI10-2

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