Plays a role in pre-mRNA splicing by promoting usage of the upstream 3′-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828).

    Matrix Type

    Gene Symbol

    UniProt ID

    Request the TLS1 Assay

    Tell us a little more about your study so we can optimize the assay for your specific needs.

    "*" indicates required fields

    This field is for validation purposes and should be left unchanged.