Isoform 2 of Nonsense-mediated mRNA decay factor SMG7;Nonsense-mediated mRNA decay factor SMG7

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • SMG7

    UniProt ID

    • Q92540

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