CHD3

Chromodomain-helicase-DNA-binding protein 3; Isoform 2 of Chromodomain-helicase-DNA-binding protein 3; Isoform 3 of Chromodomain-helicase-DNA-binding protein 3

ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666, PubMed:30397230, PubMed:9804427). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • CHD3

    UniProt ID

    • Q12873
    • Q12873-3

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