Anion exchange protein 2; Isoform B2 of Anion exchange protein 2; Isoform B1 of Anion exchange protein 2;Anion exchange protein 2

Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity). {ECO:0000250|UniProtKB:P13808, ECO:0000269|PubMed:15184086, ECO:0000269|PubMed:34668226}.

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • SLC4A2

    UniProt ID

    • P04920
    • P04920-3

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