MITOS

Mitochondrial potassium channel ATP-binding subunit; Isoform 2 of Mitochondrial potassium channel ATP-binding subunit;Mitochondrial potassium channel ATP-binding subunit; Isoform 5 of Mitochondrial potassium channel ATP-binding subunit; Isoform 4 of Mitochondrial potassium channel ATP-binding subunit

ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • ABCB8

UniProt ID

  • Q9NUT2
  • Q9NUT2-4
  • Q9NUT2-5

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