Identify and validate the most
biologically relevant small molecule biomarkers faster than ever before.
Through our proprietary rapid liquid chromatography (rLC) coupled to high resolution ion mobility mass spectrometry, Sapient can measure thousands of small molecules per sample,
across thousands of samples at a time. Chemistries captured include but are not limited to:
Accurate metabolite identification is needed to effectively map the role of key discovered small molecule biomarkers and support their translation to clinical use.
Sapient leverages our in-house standards library, encompassing >13,000 chemical reference standards, to deliver definitive identifications of up to 1,400 metabolites in large-scale studies, with >1,000 metabolites routinely identified in small-scale studies.
We have also collected >6 million MS2 spectra representing 850,000+ compounds, which can be used for putative structural identification of unknown metabolites and lipids.
Our next-generation mass spectrometry systems have an analytical cycle time of <1 minute, allowing us to process over 5,000 cellular, preclinical, and human samples per day.
That means you can have confidence in our capacity to generate results with rapid turnaround, even for large-scale discovery metabolomics and lipidomics studies.
Given the dynamic complexity of small molecule biomarkers, it is critical to understand how they behave across populations of individuals representing different lifestyles, geographies, disease states, and timepoints.
Sapient’s DynamiQ™ Insights Engine enables just that. Comprised of multi-omics data and matched real-world data from 56,000+ longitudinally collected biosamples, we can assess metabolite and lipid biomarker changes across diverse patients and over time to uncover dynamic drivers of disease and drug response.
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