DGUOK

Deoxyguanosine kinase, mitochondrial; Isoform 2 of Deoxyguanosine kinase, mitochondrial

Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:11687801, PubMed:17073823, PubMed:23043144, PubMed:8692979, PubMed:8706825). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • DGUOK

UniProt ID

  • Q16854

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