Targeted protein assays

We leverage mass spectrometry in targeted proteomics studies to deliver robust, quantitative measure of protein(s) and proteoform(s) of interest.

Targeted proteomics to advance precision drug development.

Sapient’s offers targeted protein assays and panels to deliver precise, robust insights that inform and accelerate all phases of drug development – from PK/PD studies to clinical biomarker monitoring. Explore the key differentiators of our targeted proteomics approach:

No binding agent or antibody needed

Eliminates cross-reactivity and non-specific binding while saving lengthy antibody development time.

Validation-ready assays & panels

Our off-the-shelf assays encompass >12K proteins which can undergo full validation based on your specific study.

Sample type
agnostic

Amenable to plasma/serum, tissue, tumors, CSF, urine, saliva, eye fluid, cells, media, and more.

Quantification of proteoforms

Mass spectrometry enables measure of specific protein isoforms, variants, and PTMs.

targeted proteomics

Eliminate the need for antibodies while gaining confidence in results.

targeted proteomics lab

Sapient’s high throughput mass spectrometry systems
allow us to deliver precision protein measures at scale,
processing hundreds of samples per day and providing an ideal solution for detecting and monitoring protein targets and biomarkers in clinical settings.

Our mass spectrometry method leverages labeled peptides for direct, absolute quantitation of proteins of interest in virtually any sample matrix. This targeted proteomics approach:

  • Removes the time-consuming steps required to develop and optimize detection antibodies for each protein and sample type
  • Provides multiple peptide-level measurements per protein for high specificity protein identification
  • Captures proteoforms and PTMs which can represent biologically important drug targets and biomarkers
  • Enables rapid turnaround with new assays typically deployed within 30 days

Search our Targeted Protein Assays & Panels Menu

Sapient’s off-the-shelf protein assays already encompass more than 12,000 proteins. Any of these assays can undergo full validation based on your specific study, sample type, and regulatory requirements, including for absolute quantification to deliver reproducible clinical insights. You can use the menu to filter for your protein(s) of interest by name or by signaling pathways, biological processes, and phenotypic associations to identify assays that could inform your study. Rely on our targeted proteomics  to deliver reliable, rapid insights into targets, disease status and progression, and drug response – so you can advance your study with confidence.

Don’t see your protein of interest? Sapient can perform custom assay development for bespoke & difficult-to-measure proteins, protein variants, and PTMs, including for multiplexed panels.

Why mass spectrometry for targeted proteomics?

Innovative new drug modalities are now able to target disease-modifying proteins once considered too challenging to reach. Sapient’s assays allow you to readily detect and quantify more proteins in the expanding druggable space.

Request a targeted protein assay or panel using the form.

For questions or to discuss a specific project, we encourage you to book a time to talk to our scientific team.

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