ZSWM8

Zinc finger SWIM domain-containing protein 8;Zinc finger SWIM domain-containing protein 8; Isoform 4 of Zinc finger SWIM domain-containing protein 8; Isoform 5 of Zinc finger SWIM domain-containing protein 8; Isoform 3 of Zinc finger SWIM domain-containing protein 8

Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184234, PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (PubMed:33184234, PubMed:33184237). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (PubMed:33184234). May also act as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (PubMed:24012004).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • ZSWIM8

UniProt ID

  • A7E2V4
  • A7E2V4-4
  • A7E2V4-5

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