ZMY11

Isoform 3 of Zinc finger MYND domain-containing protein 11;Zinc finger MYND domain-containing protein 11; Isoform 6 of Zinc finger MYND domain-containing protein 11

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at ‘Lys-36’ (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. ; (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • ZMYND11

UniProt ID

  • Q15326
  • Q15326-6

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