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ZFP91

E3 ubiquitin-protein ligase ZFP91

Atypical E3 ubiquitin-protein ligase that mediates ‘Lys-63’-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • ZFP91

UniProt ID

  • Q96JP5
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