WIPI2

Isoform 4 of WD repeat domain phosphoinositide-interacting protein 2; Isoform 3 of WD repeat domain phosphoinositide-interacting protein 2; Isoform 5 of WD repeat domain phosphoinositide-interacting protein 2; Isoform 4 of WD repeat domain phosphoinositide-interacting protein 2;WD repeat domain phosphoinositide-interacting protein 2; Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2; Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2;Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2; Isoform 4 of WD repeat domain phosphoinositide-interacting protein 2

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066). ; [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • WIPI2

UniProt ID

  • Q9Y4P8
  • Q9Y4P8-2
  • Q9Y4P8-3
  • Q9Y4P8-4
  • Q9Y4P8-5
  • Q9Y4P8-6

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