Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • WDFY1

    UniProt ID

    • Q8IWB7

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