TRIM1

Isoform 2 of Probable E3 ubiquitin-protein ligase MID2;Probable E3 ubiquitin-protein ligase MID2

E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the ‘Lys-48’-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954).

Matrix Type

Tissue/Cells

Gene Symbol

MID2

UniProt ID

Q9UJV3

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TRIM1

Isoform 2 of Probable E3 ubiquitin-protein ligase MID2;Probable E3 ubiquitin-protein ligase MID2

Associated with:

Matrix Type

Gene Symbol

UniProt ID

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