TR10B

Tumor necrosis factor receptor superfamily member 10B; Isoform Short of Tumor necrosis factor receptor superfamily member 10B

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • TNFRSF10B

UniProt ID

  • O14763

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