Positive regulator of ferroptosis. Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • TMEM164

UniProt ID

  • Q5U3C3

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