TINF2

TERF1-interacting nuclear factor 2; Isoform 2 of TERF1-interacting nuclear factor 2

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • TINF2

UniProt ID

  • Q9BSI4

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