TBCK

TBC domain-containing protein kinase-like protein; Isoform 2 of TBC domain-containing protein kinase-like protein; Isoform 3 of TBC domain-containing protein kinase-like protein

Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). Also involved in the modulation of mTOR signaling and expression of mTOR complex components (PubMed:23977024, PubMed:27040691). Involved in the control of actin-cytoskeleton organization (PubMed:23977024).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • TBCK

UniProt ID

  • Q8TEA7
  • Q8TEA7-3

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