SRBS2

Isoform 4 of Sorbin and SH3 domain-containing protein 2; Isoform 10 of Sorbin and SH3 domain-containing protein 2; Isoform 5 of Sorbin and SH3 domain-containing protein 2; Isoform 3 of Sorbin and SH3 domain-containing protein 2; Isoform 8 of Sorbin and SH3 domain-containing protein 2; Isoform 2 of Sorbin and SH3 domain-containing protein 2; Isoform 12 of Sorbin and SH3 domain-containing protein 2;Sorbin and SH3 domain-containing protein 2; Isoform 11 of Sorbin and SH3 domain-containing protein 2; Isoform 9 of Sorbin and SH3 domain-containing protein 2;Isoform 7 of Sorbin and SH3 domain-containing protein 2; Isoform 3 of Sorbin and SH3 domain-containing protein 2; Isoform 4 of Sorbin and SH3 domain-containing protein 2;Isoform 10 of Sorbin and SH3 domain-containing protein 2; Isoform 12 of Sorbin and SH3 domain-containing protein 2

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.

Associated with:

Matrix Type

Tissue/Cells

Gene Symbol

SORBS2

UniProt ID

O94875
O94875-10
O94875-11
O94875-12
O94875-2
O94875-3
O94875-4
O94875-5
O94875-7
O94875-8
O94875-9

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SRBS2

Associated with:

Matrix Type

Gene Symbol

UniProt ID

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