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SPT13;ARHG4;ARHG9

Isoform 6 of Spermatogenesis-associated protein 13; Isoform 4 of Spermatogenesis-associated protein 13;Rho guanine nucleotide exchange factor 9; Isoform 3 of Rho guanine nucleotide exchange factor 4; Spermatogenesis-associated protein 13; Isoform 5 of Spermatogenesis-associated protein 13; Isoform 3 of Rho guanine nucleotide exchange factor 9; Isoform 2 of Rho guanine nucleotide exchange factor 9; Isoform 4 of Rho guanine nucleotide exchange factor 4; Isoform 2 of Spermatogenesis-associated protein 13; Rho guanine nucleotide exchange factor 4; Isoform 3 of Spermatogenesis-associated protein 13

Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • SPATA13

    UniProt ID

    • O43307
    • O43307-3
    • Q96N96
    • Q96N96-2
    • Q96N96-3
    • Q96N96-4
    • Q96N96-5
    • Q96N96-6
    • Q9NR80
    • Q9NR80-3
    • Q9NR80-4
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