SPN90

NCK-interacting protein with SH3 domain; Isoform 3 of NCK-interacting protein with SH3 domain;NCK-interacting protein with SH3 domain

Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis.

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • NCKIPSD

    UniProt ID

    • Q9NZQ3

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