SCUB2

Signal peptide, CUB and EGF-like domain-containing protein 2; Isoform 3 of Signal peptide, CUB and EGF-like domain-containing protein 2; Isoform 2 of Signal peptide, CUB and EGF-like domain-containing protein 2

Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22677548, PubMed:22902404). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).

Associated with:

Late Estrogen Response

Matrix Type

Tissue/Cells

Gene Symbol

SCUBE2

UniProt ID

Q9NQ36
Q9NQ36-3

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SCUB2

Signal peptide, CUB and EGF-like domain-containing protein 2; Isoform 3 of Signal peptide, CUB and EGF-like domain-containing protein 2; Isoform 2 of Signal peptide, CUB and EGF-like domain-containing protein 2

Associated with:

Matrix Type

Gene Symbol

UniProt ID

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