Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5′ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5′ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5′ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5′ end of the U1 snRNA and the 5′ splice-site region.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • SNRPC

    UniProt ID

    • P09234

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