PTPRA

Receptor-type tyrosine-protein phosphatase alpha; Isoform 2 of Receptor-type tyrosine-protein phosphatase alpha;Receptor-type tyrosine-protein phosphatase alpha

Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • PTPRA

UniProt ID

  • P18433

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