Isoform 2 of PH and SEC7 domain-containing protein 4;PH and SEC7 domain-containing protein 4

Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • PSD4

    UniProt ID

    • Q8NDX1

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