PROP

Properdin

A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604).

Associated with:

Alanine Transaminase
Albumin
Alcohol Dependence
Alkaline Phosphatase
Angina Pectoris
Apolipoprotein A
Apolipoprotein B
Arteriosclerosis
Aspartate Transaminase
Asthma
Atrial Fibrillation
Basal Metabolic Rate
Basophils
Bilirubin
BMI
C Reactive Protein
Calcium
Calcium Albumin Ratio
Cancer
Chronic Ischaemic Heart Disease
Chronic Lymphocytic Leukemia And Small Lymphocytic Lymphoma
Chronic Obstructive Pulmonary Disease
Creatinine
Cystatin C
Diastolic Blood Pressure
Direct Bilirubin
Emphysema
Eosinophils
Erythrocyte Sedimentation Rate
Estimated Glomerular Filtration Rate
Ferritin
Fluid Intelligence
Folate
FT3 FT4 Ratio
Gallstones
Gamma Glutamyltransferase
Gastroesophageal Reflux
Glucose
Granulocytes
HbA1c
Heart Failure
Heartrate
Height
Hematocrit
Hemoglobin
High Density Lipoprotein Cholesterol
Hypertension
Hypotension
IGF1
Kidney Failure
Knee Osteoarthritis
Lactate Dehydrogenase
Leukocytes
Lipoprotein A
Low Density Lipoprotein Cholesterol
Lymphocytes
Metabolic Acidosis
Metabolic Syndrome
Monocytes
Myocardial Infarction
Neutrophils
Oestradiol
Peripheral Vascular Disease
Phneumonia
Phobias
Physical Activity
Platelet
Red Blood Cell Count
Respiratory Alkalosis
Respiratory Failure
Reticulocytes
Rheumatoid Arthritis
Severe Obesity (BMI > 35)
Sodium
Spine Bone Mineral Density
Stomach Cancer
Systemic Lupus
Systolic Blood Pressure
Testosterone
Thyroid FT3
Total Bilirubin
Total Cholesterol
Total Fat
Total Lean Muscle
Triglyceride
Type 2 Diabetes
Urea
Uric Acid
Vitamin D
Waist Circumference
Waist Hip Ratio
Weight
White Blood Cell
Whole Body Fat
Complement
MTORC1 Signaling
Allograft Rejection
Innate Immune Response

Matrix Type

Plasma
Tissue/Cells

Gene Symbol

UniProt ID

P27918

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PROP

Properdin

Associated with:

Matrix Type

Gene Symbol

UniProt ID

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