PPIE

Peptidyl-prolyl cis-trans isomerase E; Isoform 3 of Peptidyl-prolyl cis-trans isomerase E; Isoform B of Peptidyl-prolyl cis-trans isomerase E

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:18258190, PubMed:20460131, PubMed:20677832, PubMed:8977107). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3′-UTR of mRNA molecules (PubMed:18258190, PubMed:20460131, PubMed:8977107). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:18258190, PubMed:20541251, PubMed:20677832, PubMed:8977107). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20460131, PubMed:20541251, PubMed:20677832).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • PPIE

UniProt ID

  • Q9UNP9
  • Q9UNP9-3

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