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PLPL6

Isoform 2 of Patatin-like phospholipase domain-containing protein 6;Patatin-like phospholipase domain-containing protein 6; Isoform 3 of Patatin-like phospholipase domain-containing protein 6;Patatin-like phospholipase domain-containing protein 6

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584).

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • PNPLA6

    UniProt ID

    • Q8IY17
    • Q8IY17-3
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