PDLI5

PDZ and LIM domain protein 5;Isoform 4 of PDZ and LIM domain protein 5; Isoform 7 of PDZ and LIM domain protein 5

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation.

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • PDLIM5

UniProt ID

  • Q96HC4
  • Q96HC4-4

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